Hypoxia-Inducible Factors in Physiology and Medicine
نویسنده
چکیده
Oxygen homeostasis represents an organizing principle for understanding metazoan evolution, development, physiology, and pathobiology. The hypoxia-inducible factors (HIFs) are transcriptional activators that function as master regulators of oxygen homeostasis in all metazoan species. Rapid progress is being made in elucidating homeostatic roles of HIFs in many physiological systems, determining pathological consequences of HIF dysregulation in chronic diseases, and investigating potential targeting of HIFs for therapeutic purposes.
منابع مشابه
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ورودعنوان ژورنال:
- Cell
دوره 148 شماره
صفحات -
تاریخ انتشار 2012